Ontology highlight
ABSTRACT:
SUBMITTER: He K
PROVIDER: S-EPMC5651867 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
He Kangmin K Sakai Tsuyoshi T Tsukasaki Yoshikazu Y Watanabe Tomonobu M TM Ikebe Mitsuo M
Scientific reports 20171020 1
Filopodia protrude from the leading edge of cells and play important roles in cell motility. Here we report the mechanism of myosin X (encoded by Myo10)-induced multi-cycle filopodia extension. We found that actin, Arp2/3, vinculin and integrin-β first accumulated at the cell's leading edge. Myosin X was then gathered at these sites, gradually clustered by lateral movement, and subsequently initiated filopodia formation. During filopodia extension, we found the translocation of Arp2/3 and integr ...[more]