Unknown

Dataset Information

0

Antimicrobial Nonsusceptibility of Gram-Negative Bloodstream Isolates, Veterans Health Administration System, United States, 2003-20131.


ABSTRACT: Bacteremia caused by gram-negative bacteria is associated with serious illness and death, and emergence of antimicrobial drug resistance in these bacteria is a major concern. Using national microbiology and patient data for 2003-2013 from the US Veterans Health Administration, we characterized nonsusceptibility trends of community-acquired, community-onset; healthcare-associated, community-onset; and hospital-onset bacteremia for selected gram-negative bacteria (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, and Acinetobacter spp.). For 47,746 episodes of bacteremia, the incidence rate was 6.37 episodes/10,000 person-years for community-onset bacteremia and 4.53 episodes/10,000 patient-days for hospital-onset bacteremia. For Klebsiella spp., P. aeruginosa, and Acinetobacter spp., we observed a decreasing proportion of nonsusceptibility across nearly all antimicrobial drug classes for patients with healthcare exposure; trends for community-acquired, community-onset isolates were stable or increasing. The role of infection control and antimicrobial stewardship efforts in inpatient settings in the decrease in drug resistance rates for hospital-onset isolates needs to be determined.

SUBMITTER: Goto M 

PROVIDER: S-EPMC5652419 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4560406 | biostudies-other
| S-EPMC8005515 | biostudies-literature
| S-EPMC6668032 | biostudies-literature
| S-EPMC9951917 | biostudies-literature
| S-EPMC8504347 | biostudies-literature
| S-EPMC5720754 | biostudies-literature
| S-EPMC5731700 | biostudies-literature
| S-EPMC5710211 | biostudies-literature
| S-EPMC5571292 | biostudies-literature
2008-02-26 | GSE7163 | GEO