Dataset Information

Virulence of Japanese Encephalitis Virus Genotypes I and III, Taiwan.

ABSTRACT: The virulence of genotype I (GI) Japanese encephalitis virus (JEV) is under debate. We investigated differences in the virulence of GI and GIII JEV by calculating asymptomatic ratios based on serologic studies during GI- and GIII-JEV endemic periods. The results suggested equal virulence of GI and GIII JEV among humans.

SUBMITTER: Fan YC

PROVIDER: S-EPMC5652437 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Virulence of Japanese Encephalitis Virus Genotypes I and III, Taiwan.

Fan Yi-Chin YC Lin Jen-Wei JW Liao Shu-Ying SY Chen Jo-Mei JM Chen Yi-Ying YY Chiu Hsien-Chung HC Shih Chen-Chang CC Chen Chi-Ming CM Chang Ruey-Yi RY King Chwan-Chuen CC Chen Wei-June WJ Ko Yi-Ting YT Chang Chao-Chin CC Chiou Shyan-Song SS

Emerging infectious diseases 20171101 11

The virulence of genotype I (GI) Japanese encephalitis virus (JEV) is under debate. We investigated differences in the virulence of GI and GIII JEV by calculating asymptomatic ratios based on serologic studies during GI- and GIII-JEV endemic periods. The results suggested equal virulence of GI and GIII JEV among humans. ...[more]

PMID: 29048288

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Project description:UnlabelledJapanese encephalitis (JE) is an arthropod-borne disease associated with the majority of viral encephalitis cases in the Asia-Pacific region. The causative agent, Japanese encephalitis virus (JEV), has been phylogenetically divided into five genotypes. Recent surveillance data indicate that genotype I (GI) is gradually replacing genotype III (GIII) as the dominant genotype. To investigate the mechanism behind the genotype shift and the potential consequences in terms of vaccine efficacy, human cases, and virus dissemination, we collected (i) all full-length and partial JEV molecular sequences and (ii) associated genotype and host information comprising a data set of 873 sequences. We then examined differences between the two genotypes at the genetic and epidemiological level by investigating amino acid mutations, positive selection, and host range. We found that although GI is dominant, it has fewer sites predicted to be under positive selection, a narrower host range, and significantly fewer human isolates. For the E protein, the sites under positive selection define a haplotype set for each genotype that shows striking differences in their composition and diversity, with GIII showing significantly more variety than GI. Our results suggest that GI has displaced GIII by achieving a replication cycle that is more efficient but is also more restricted in its host range.ImportanceJapanese encephalitis is an arthropod-borne disease associated with the majority of viral encephalitis cases in the Asia-Pacific region. The causative agent, Japanese encephalitis virus (JEV), has been divided into five genotypes based on sequence similarity. Recent data indicate that genotype I (GI) is gradually replacing genotype III (GIII) as the dominant genotype. Understanding the reasons behind this shift and the potential consequences in terms of vaccine efficacy, human cases, and virus dissemination is important for controlling the spread of the virus and reducing human fatalities. We collected all available full-length and partial JEV molecular sequences and associated genotype and host information. We then examined differences between the two genotypes at the genetic and epidemiological levels by investigating amino acid mutations, positive selection, and host range. Our results suggest that GI has displaced GIII by achieving a replication cycle that is more efficient but more restricted in host range.

Dataset Information

Virulence of Japanese Encephalitis Virus Genotypes I and III, Taiwan.

Publications

Virulence of Japanese Encephalitis Virus Genotypes I and III, Taiwan.

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