Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes.

ABSTRACT:

Objective

To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D).

Research design and methods

Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and myocardial perfusion were measured with [¹⁸F]fluoro-2-deoxy-d-glucose and [¹⁵O]H₂O positron emission tomography before and after 24 weeks of pioglitazone treatment. Myocardial function and transmitral early diastolic relation/atrial contraction (E/A) flow ratio were measured with magnetic resonance imaging.

Results

Pioglitazone reduced HbA_1c by 0.9%; decreased systolic and diastolic blood pressure by 7 ± 2 and

SUBMITTER: Clarke GD 

PROVIDER: S-EPMC5652586 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature