Low BUB1 expression is an adverse prognostic marker in gastric adenocarcinoma.
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ABSTRACT:
SUBMITTER: Stahl D
PROVIDER: S-EPMC5652709 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Low BUB1 expression is an adverse prognostic marker in gastric adenocarcinoma.
Stahl David D Braun Martin M Gentles Andrew J AJ Lingohr Philipp P Walter Adeline A Kristiansen Glen G Gütgemann Ines I
Oncotarget 20170718 44
Gastric adenocarcinomas are associated with a poor prognosis due to the fact that the tumor has often metastasized by the time of diagnosis and prognostic markers are urgently needed to tailor treatment. We examined the expression of the mitotic spindle checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) and Ki-67 protein expression by immunohistochemistry in 218 patients with primary gastric adenocarcinomas. Tumors with low frequency of BUB1 expression were associated with larger ...[more]
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