Ontology highlight
ABSTRACT:
SUBMITTER: Qu H
PROVIDER: S-EPMC5653223 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Qu Hao H Csordas Andrew T AT Wang Jinpeng J Oh Seung Soo SS Eisenstein Michael S MS Soh Hyongsok Tom HT
ACS nano 20160711 8
Generating aptamers that bind to specific metal ions is challenging because existing aptamer discovery methods typically require chemical labels or modifications that can alter the structure and properties of the ions. In this work, we report an aptamer discovery method that enables us to generate high-quality structure-switching aptamers (SSAs) that undergo a conformational change upon binding a metal ion target, without the requirement of labels or chemical modifications. Our method is more ef ...[more]