Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Dominguez C
PROVIDER: S-EPMC5653516 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Alvarez-Dominguez Carmen C Calderón-Gonzalez Ricardo R Terán-Navarro Hector H Salcines-Cuevas David D Garcia-Castaño Almudena A Freire Javier J Gomez-Roman Javier J Rivera Fernando F
Annals of translational medicine 20171001 19
Dendritic cell (DC) vaccines are cancer vaccines used currently as melanoma therapies. They act as adjuvants initiating the immune responses, but not only as they can also have effector activities redirecting cytotoxic CD8<sup>+</sup> T cells against melanoma. Ex vivo preparation of monocyte derived DCs has been implemented to produce large numbers of DCs for clinical therapy, highlighting the necessity of activate DC s to produce Th1 cytokines, especially TNF-a and IL-12 with potent anti-tumour ...[more]