Ontology highlight
ABSTRACT:
SUBMITTER: Semrau S
PROVIDER: S-EPMC5653659 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Semrau Stefan S Goldmann Johanna E JE Soumillon Magali M Mikkelsen Tarjei S TS Jaenisch Rudolf R van Oudenaarden Alexander A
Nature communications 20171023 1
Gene expression heterogeneity in the pluripotent state of mouse embryonic stem cells (mESCs) has been increasingly well-characterized. In contrast, exit from pluripotency and lineage commitment have not been studied systematically at the single-cell level. Here we measure the gene expression dynamics of retinoic acid driven mESC differentiation from pluripotency to lineage commitment, using an unbiased single-cell transcriptomics approach. We find that the exit from pluripotency marks the start ...[more]