Ontology highlight
ABSTRACT:
SUBMITTER: Boyle MJ
PROVIDER: S-EPMC5653696 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Boyle Michelle J MJ Jagannathan Prasanna P Bowen Katherine K McIntyre Tara I TI Vance Hilary M HM Farrington Lila A LA Schwartz Alanna A Nankya Felistas F Naluwu Kate K Wamala Samuel S Sikyomu Esther E Rek John J Greenhouse Bryan B Arinaitwe Emmanuel E Dorsey Grant G Kamya Moses R MR Feeney Margaret E ME
Frontiers in immunology 20171019
Cytokine-producing CD4 T cells have important roles in immunity against <i>Plasmodium falciparum (Pf)</i> malaria. However, the factors influencing functional differentiation of <i>Pf-</i>specific CD4 T cells in naturally exposed children are not well understood. Moreover, it is not known which CD4 T-cell cytokine-producing subsets are most critical for protection. We measured <i>Pf-</i>specific IFNγ-, IL10-, and TNFα-producing CD4 T-cell responses by multi-parametric flow cytometry in 265 child ...[more]