Unknown

Dataset Information

0

Identifying treatment response to antihypertensives in patients with obesity-related hypertension.


ABSTRACT: BACKGROUND:In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics. METHODS:Effects of aliskiren, moxonidine and hydrochlorothiazide on 24-h blood pressure (BP) were compared to placebo. Linear mixed effect models were used to analyze the effect of patient characteristics on BP levels and treatment response. RESULTS:Systolic BP response to aliskiren was higher in patients with a BMI >?30.7 kg/m2 compared to patients with a BMI ??30.7 kg/m2 (-21 mmHg versus -4 mmHg). In patients with a hsCRP >?1.8 mg/L the systolic BP response to aliskiren was higher than in patients with a low hsCRP (-15 mmHg versus -7 mmHg). Hydrochlorothiazide (HCTZ) treatment effect on systolic BP was -13 mmHg when heart rate >?71 beats/min compared to -3 mmHg when heart rate was ??71 beats/min. CONCLUSION:In patients with ORH, BP response to aliskiren is positively related to BMI and hsCRP. Systolic BP response to HCTZ is positively related to heart rate and negatively to renin levels. TRIAL REGISTRATION:NCT01138423. Registered June 4th, 2010.

SUBMITTER: Schrover IM 

PROVIDER: S-EPMC5654008 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

Identifying treatment response to antihypertensives in patients with obesity-related hypertension.

Schrover Ilse M IM   Dorresteijn Jannick A N JAN   Smits Jodine E JE   Danser A H Jan AHJ   Visseren Frank L J FLJ   Spiering Wilko W  

Clinical hypertension 20171024


<h4>Background</h4>In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics.<h4>Methods</h4>Effects of aliskiren, moxonidine and hydrochlorothiazide on 24-h blood pressure (BP) were compared to placebo. Linear mixed effect models were used to analyze the effect of patient characteristics on BP levels and treatment response.<h4>Results</h4>Systolic BP response to aliskiren was higher in patients with a BMI > 30.7 k  ...[more]

Similar Datasets

| S-EPMC4349578 | biostudies-literature
| S-EPMC7202991 | biostudies-literature
| S-EPMC10238046 | biostudies-literature
| S-EPMC5976467 | biostudies-literature
| S-EPMC3529147 | biostudies-literature
| S-EPMC7678114 | biostudies-literature
| S-EPMC9799038 | biostudies-literature
| S-EPMC9604511 | biostudies-literature
| S-EPMC9470735 | biostudies-literature
| S-EPMC6600840 | biostudies-literature