Ontology highlight
ABSTRACT:
SUBMITTER: Vogl G
PROVIDER: S-EPMC5654503 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Vogl G G Lesiak I I Jensen D B DB Perkhofer S S Eck R R Speth C C Lass-Flörl C C Zipfel P F PF Blom A M AM Dierich M P MP Würzner R R
Molecular immunology 20071025 5
Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections. Although the impaired immune status of the host is clearly the most important factor leading to disease, virulence factors of the fungus also play a role. Factor H (FH) and its splice product FHL-1 represent the major fluid phase inhibitors of the alternative pathway of complement, whereas C4b-binding protein (C4bp) is the main fluid phase inh ...[more]