Ontology highlight
ABSTRACT:
SUBMITTER: Ge L
PROVIDER: S-EPMC5654509 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Ge Lin L Villinger Saskia S Mari Stefania A SA Giller Karin K Griesinger Christian C Becker Stefan S Müller Daniel J DJ Zweckstetter Markus M
Structure (London, England : 1993) 20160324 4
The voltage-dependent anion channel (VDAC) regulates the flux of metabolites and ions across the outer mitochondrial membrane. Regulation of ion flow involves conformational transitions in VDAC, but the nature of these changes has not been resolved to date. By combining single-molecule force spectroscopy with nuclear magnetic resonance spectroscopy we show that the β barrel of human VDAC embedded into a membrane is highly flexible. Its mechanical flexibility exceeds by up to one order of magnitu ...[more]