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Fabrication of Ultrathin Zn(OH)2 Nanosheets as Drug Carriers.

ABSTRACT: Ultrathin two-dimensional (2D) porous Zn(OH)2 nanosheets (PNs) have been fabricated by using one-dimensional Cu nanowires as backbones. PNs have thicknesses of about 3.8 nm and pore sizes of 4~10 nm. To form "smart" porous nanosheets, DNA aptamers were covalently conjugated on the surface of PNs. These ultrathin nanosheets show good biocompatibility, efficient cellular uptake, and promising pH-stimulated drug release.

SUBMITTER: Cai R 

PROVIDER: S-EPMC5654576 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Fabrication of Ultrathin Zn(OH)<sub>2</sub> Nanosheets as Drug Carriers.

Cai Ren R   Yang Dan D   Wu Jin J   Zhang Liqin L   Wu Cuichen C   Chen Xigao X   Wang Yanyue Y   Wan Shuo S   Hou Fengwei F   Yan Qingyu Q   Tan Weihong W  

Nano research 20160610 8

Ultrathin two-dimensional (2D) porous Zn(OH)<sub>2</sub> nanosheets (PNs) have been fabricated by using one-dimensional Cu nanowires as backbones. PNs have thicknesses of about 3.8 nm and pore sizes of 4~10 nm. To form "smart" porous nanosheets, DNA aptamers were covalently conjugated on the surface of PNs. These ultrathin nanosheets show good biocompatibility, efficient cellular uptake, and promising pH-stimulated drug release. ...[more]

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