Ontology highlight
ABSTRACT:
SUBMITTER: Caroccia B
PROVIDER: S-EPMC5654760 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Caroccia Brasilina B Menegolo Mirko M Seccia Teresa M TM Petrelli Lucia L Antonello Michele M Limena Alice A Porzionato Andrea A De Caro Raffaele R Poglitsch Marko M Rossi Gian Paolo GP
Scientific reports 20171024 1
We investigated the in vivo pressor effects of the potent vasoconstrictor Urotensin II (UII). We randomized normotensive Sprague-Dawley rats into 4 groups that received a 7-day UII infusion (cases) or vehicle (controls). Group 1 received normal sodium intake; Group 2 underwent unilateral nephrectomy and salt loading; Group 3 received spironolactone, besides unilateral nephrectomy and salt loading; Group 4 only received spironolactone. UII raised BP transiently after a lag phase of 12-36 hours in ...[more]