Dataset Information

Cytocompatibility and antibacterial activity of nanostructured H2Ti5O11·H2O outlayered Zn-doped TiO2 coatings on Ti for percutaneous implants.

ABSTRACT: To improve skin-integration and antibacterial activity of percutaneous implants, the coatings comprising an outer layer of H2Ti5O11·H2O (HTO) nanoarrays and an inner layer of microporous Zn-doped TiO2 were fabricated on Ti by micro-arc oxidation (MAO) followed with hydrothermal treatment (HT). During HT process, a large proportion of Zn2+ migrated out from TiO2 layer. TiO2 reacted with OH- and H2O, resulting in the nucleation of HTO. The nuclei grew to nanoplates, nanorods and nanofibres with HT process prolonged. Simultaneously, the orientation of nanoarrays changed from quasi-vertical to parallel to substrate. Compared to Ti, adhesion and proliferation of fibroblasts were enhanced on as-MAOed TiO2 and HTed coatings. The phenotype, differentiation and extracellular collagen secretion were obviously accelerated on vertical nanorods with proper interspace (e.g. 63 nm). HTed coatings showed enhanced antibacterial activity, which should be ascribed to the nano-topography of HTO.

SUBMITTER: Zhang L

PROVIDER: S-EPMC5654996 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Cytocompatibility and antibacterial activity of nanostructured H2Ti5O11·H2O outlayered Zn-doped TiO2 coatings on Ti for percutaneous implants.

Zhang Lan L Zhang Juan J Dai Fang F Han Yong Y

Scientific reports 20171024 1

To improve skin-integration and antibacterial activity of percutaneous implants, the coatings comprising an outer layer of H2Ti5O11·H2O (HTO) nanoarrays and an inner layer of microporous Zn-doped TiO2 were fabricated on Ti by micro-arc oxidation (MAO) followed with hydrothermal treatment (HT). During HT process, a large proportion of Zn2+ migrated out from TiO2 layer. TiO2 reacted with OH- and H<su ...[more]

PMID: 29066726

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Project description:Magnesium (Mg) and its alloys have shown attractive biocompatibility and mechanical strength for medical applications, but low corrosion resistance of Mg in physiological environment limits its broad clinical translation. Hydroxyapatite (HA) nanoparticles (nHA) are promising coating materials for decreasing degradation rates and prolonging mechanical strength of Mg-based implants while enhancing bone healing due to their osteoconductivity and osteoinductivity. Conformal HA coatings with nano-to-submicron structures, namely nHA and mHA coatings, were deposited successfully on Mg plates and rods using a transonic particle acceleration (TPA) process under two different conditions, characterized, and investigated for their effects on Mg degradation in vitro. The nHA and mHA coatings enhanced corrosion resistance of Mg and retained 86-90% of ultimate compressive strength after in vitro immersion in rSBF for 6 weeks, much greater than non-coated Mg that only retained 66% of strength. Mg-based rods with or without coatings showed slower degradation than the respective Mg-based plates in rSBF after 6 weeks, likely because of the greater surface-to-volume ratio of Mg plates than Mg rods. This indicates that Mg-based plate and screw devices may undergo different degradation even when they have the same coatings and are implanted at the same or similar anatomical locations. Therefore, in addition to locations of implantation, the geometry, dimension, surface area, volume, and mass of Mg-based implants and devices should be carefully considered in their design and processing to ensure that they not only provide adequate structural and mechanical stability for bone fixation, but also support the functions of bone cells, as clinically required for craniomaxillofacial (CMF) and orthopedic implants. When the nHA and mHA coated Mg and non-coated Mg plates were cultured with bone marrow derived mesenchymal stem cells (BMSCs) using the in vitro direct culture method, greater cell adhesion densities were observed under indirect contact conditions than that under direct contact conditions for the nHA and mHA coated Mg. In comparison with non-coated Mg, the nHA and mHA coated Mg reduced BMSC adhesion densities directly on the surface, but increased the average BMSC adhesion densities under indirect contact. Further long-term studies in vitro and in vivo are necessary to elucidate the effects of nHA and mHA coatings on cell functions and tissue healing.

Dataset Information

Cytocompatibility and antibacterial activity of nanostructured H2Ti5O11·H2O outlayered Zn-doped TiO2 coatings on Ti for percutaneous implants.

Publications

Cytocompatibility and antibacterial activity of nanostructured H<sub>2</sub>Ti<sub>5</sub>O<sub>11</sub>·H<sub>2</sub>O outlayered Zn-doped TiO<sub>2</sub> coatings on Ti for percutaneous implants.

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