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In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives.

ABSTRACT: The in vitro activities of novel azoles compared to those of five antifungal drugs against clinical (n = 28) and environmental (n = 102) isolates of black mold and melanized yeast were determined. Luliconazole and lanoconazole had the lowest geometric mean MICs, followed by efinaconazole, against tested isolates compared to the other drugs. Therefore, it appears that these new imidazole and triazole drugs are promising candidates for the treatment of infections due to melanized fungi and their relatives.

SUBMITTER: Shokoohi GR

PROVIDER: S-EPMC5655049 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives.

Shokoohi Gholam Reza GR Badali Hamid H Mirhendi Hossein H Ansari Saham S Rezaei-Matehkolaei Ali A Ahmadi Bahram B Vaezi Afsane A Alshahni Mohamed Mahdi MM Makimura Koichi K

Antimicrobial agents and chemotherapy 20171024 11

The in vitro activities of novel azoles compared to those of five antifungal drugs against clinical (n = 28) and environmental (n = 102) isolates of black mold and melanized yeast were determined. Luliconazole and lanoconazole had the lowest geometric mean MICs, followed by efinaconazole, against tested isolates compared to the other drugs. Therefore, it appears that these new imidazole and triazole drugs are promising candidates for the treatment of infections due to melani ...[more]

PMID: 28848012

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