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PBP4 Mediates ?-Lactam Resistance by Altered Function.

ABSTRACT: Penicillin binding protein 4 (PBP4) can provide high-level ?-lactam resistance in Staphylococcus aureus A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the ?-lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of pbp4 Our results also suggest a cooperative interplay among PBPs for ?-lactam resistance.

SUBMITTER: Chatterjee SS 

PROVIDER: S-EPMC5655059 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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PBP4 Mediates β-Lactam Resistance by Altered Function.

Chatterjee Som S SS   Chen Liang L   Gilbert Aubre A   da Costa Thaina M TM   Nair Vinod V   Datta Sandip K SK   Kreiswirth Barry N BN   Chambers Henry F HF  

Antimicrobial agents and chemotherapy 20171024 11

Penicillin binding protein 4 (PBP4) can provide high-level β-lactam resistance in <i>Staphylococcus aureus</i> A series of missense and promoter mutations associated with <i>pbp4</i> were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the β-lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of <i>pbp4</i> Our results also suggest a cooperative interplay among PBPs for β-lactam resistance. ...[more]

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