Ontology highlight
ABSTRACT:
SUBMITTER: Aarnoutse RE
PROVIDER: S-EPMC5655063 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Aarnoutse R E RE Kibiki G S GS Reither K K Semvua H H HH Haraka F F Mtabho C M CM Mpagama S G SG van den Boogaard J J Sumari-de Boer I M IM Magis-Escurra C C Wattenberg M M Logger J G M JGM Te Brake L H M LHM Hoelscher M M Gillespie S H SH Colbers A A Phillips P P J PPJ Plemper van Balen G G Boeree M J MJ
Antimicrobial agents and chemotherapy 20171024 11
In a multiple-dose-ranging trial, we previously evaluated higher doses of rifampin in patients for 2 weeks. The objectives of the current study were to administer higher doses of rifampin for a longer period to compare the pharmacokinetics, safety/tolerability, and bacteriological activity of such regimens. In a double-blind, randomized, placebo-controlled, phase II clinical trial, 150 Tanzanian patients with tuberculosis (TB) were randomized to receive either 600 mg (approximately 10 mg/kg of b ...[more]