Ontology highlight
ABSTRACT:
SUBMITTER: Metcalfe JZ
PROVIDER: S-EPMC5655066 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Metcalfe John Z JZ Streicher Elizabeth E Theron Grant G Colman Rebecca E RE Penaloza Renee R Allender Christopher C Lemmer Darrin D Warren Robin M RM Engelthaler David M DM
Antimicrobial agents and chemotherapy 20171024 11
Multidrug-resistant tuberculosis (TB) presents a major public health dilemma. Heteroresistance, the coexistence of drug-resistant and drug-susceptible strains or of multiple drug-resistant strains with discrete haplotypes, may affect accurate diagnosis and the institution of effective treatment. Subculture, or passage of cells onto fresh growth medium, is utilized to preserve <i>Mycobacterium tuberculosis</i> cell lines and is universally employed in TB diagnostics. The impact of such passages, ...[more]