Role of growth differentiation factor 11 in development, physiology and disease.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5655313 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Role of growth differentiation factor 11 in development, physiology and disease.
Zhang Yonghui Y Wei Yong Y Liu Dan D Liu Feng F Li Xiaoshan X Pan Lianhong L Pang Yi Y Chen Dilong D
Oncotarget 20170814 46
Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates Smad and non-Smad signaling pathways and regulates expression of its target nuclear genes. Since its discovery in 1999, studies have shown the involvement of GDF11 in normal physiological processes, such as embryonic development and erythropoiesis, as well as in the pathophysiology of aging, cardiovascular disease, diabetes mellitus, and cancer. In addition, there are contradictory reports regarding the rol ...[more]
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