Ontology highlight
ABSTRACT:
SUBMITTER: Prats E
PROVIDER: S-EPMC5655329 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Prats Eva E Gómez-Canela Cristian C Ben-Lulu Shani S Ziv Tamar T Padrós Francesc F Tornero Daniel D Garcia-Reyero Natàlia N Tauler Romà R Admon Arie A Raldúa Demetrio D
Scientific reports 20171024 1
Acrylamide (ACR), a type-2 alkene, may lead to a synaptopathy characterized by ataxia, skeletal muscles weakness and numbness of the extremities in exposed human and laboratory animals. Currently, only the mildly affected patients undergo complete recovery, and identification of new molecules with therapeutic bioactivity against ACR acute neurotoxicity is urgently needed. Here, we have generated a zebrafish model for ACR neurotoxicity by exposing 5 days post-fertilization zebrafish larvae to 1 m ...[more]