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ABSTRACT: Introduction
It is unclear whether the treatment of an HIV infection with highly active antiretroviral therapy (HAART) affects intensive care unit (ICU) outcomes. In this paper, we report the results of a systematic review and meta-analysis performed to summarize the effects of HAART on the prognosis of critically ill HIV positive patients.Materials and methods
A bibliographic search was performed in 3 databases (PubMed, Web of Science and Scopus) to identify articles that investigated the use of HAART during ICU admissions for short- and long-term mortality or survival. Eligible articles were selected in a staged process and were independently assessed by two investigators. The methodological quality of the selected articles was evaluated using the Methodological Index for Non-Randomized Studies (MINORS) tool.Results
Twelve articles met the systematic review inclusion criteria and examined short-term mortality. Six of them also examined long-term mortality (≥90 days) after ICU discharge. The short-term mortality meta-analysis showed a significant beneficial effect of initiating or maintaining HAART during the ICU stay (random effects odds ratio 0.53, p = 0.02). The data analysis of long-term outcomes also suggested a reduced mortality when HAART was used, but the effect of HAART on long-term mortality of HIV positive critically ill patients remains uncertain.Conclusions
This meta-analysis suggests improved survival rates for HIV positive patients who were treated with HAART during their ICU admission.
SUBMITTER: Andrade HB
PROVIDER: S-EPMC5655356 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Andrade Hugo Boechat HB Shinotsuka Cassia Righy CR da Silva Ivan Rocha Ferreira IRF Donini Camila Sunaitis CS Yeh Li Ho H de Carvalho Frederico Bruzzi FB Americano do Brasil Pedro Emmanuel Alvarenga PEA Bozza Fernando Augusto FA Miguel Japiassu Andre A
PloS one 20171024 10
<h4>Introduction</h4>It is unclear whether the treatment of an HIV infection with highly active antiretroviral therapy (HAART) affects intensive care unit (ICU) outcomes. In this paper, we report the results of a systematic review and meta-analysis performed to summarize the effects of HAART on the prognosis of critically ill HIV positive patients.<h4>Materials and methods</h4>A bibliographic search was performed in 3 databases (PubMed, Web of Science and Scopus) to identify articles that invest ...[more]