Relevance of Lipid-Based Products in the Management of Dry Eye Disease.

ABSTRACT: Components of the ocular surface synergistically contribute to maintaining and protecting a smooth refractive layer to facilitate the optimal transmission of light. At the air-water interface, the tear film lipid layer (TFLL), a mixture of lipids and proteins, plays a key role in tear surface tension and is important for the physiological hydration of the ocular surface and for ocular homeostasis. Alterations in tear fluid rheology, differences in lipid composition, or downregulation of specific tear proteins are found in most types of ocular surface disease, including dry eye disease (DED). Artificial tears have long been a first line of treatment in DED and aim to replace or supplement tears. More recently, lipid-containing eye drops have been developed to more closely mimic the combinat

SUBMITTER: Garrigue JS 

PROVIDER: S-EPMC5655476 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature