Ontology highlight
ABSTRACT:
SUBMITTER: Safikhani Z
PROVIDER: S-EPMC5655668 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Safikhani Zhaleh Z Smirnov Petr P Thu Kelsie L KL Silvester Jennifer J El-Hachem Nehme N Quevedo Rene R Lupien Mathieu M Mak Tak W TW Cescon David D Haibe-Kains Benjamin B
Nature communications 20171024 1
Next-generation sequencing technologies have recently been used in pharmacogenomic studies to characterize large panels of cancer cell lines at the genomic and transcriptomic levels. Among these technologies, RNA-sequencing enable profiling of alternatively spliced transcripts. Given the high frequency of mRNA splicing in cancers, linking this feature to drug response will open new avenues of research in biomarker discovery. To identify robust transcriptomic biomarkers for drug response across s ...[more]