Ontology highlight
ABSTRACT:
SUBMITTER: Davidson D
PROVIDER: S-EPMC5656005 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Davidson Dominique D Zhong Ming-Chao MC Pandolfi Pier Paolo PP Bolland Silvia S Xavier Ramnik J RJ Seed Brian B Li Xin X Gu Hua H Veillette André A
Cell reports 20161201 10
The transmembrane adaptor PAG (Cbp) has been proposed to mediate membrane recruitment of Csk, a cytoplasmic protein tyrosine kinase playing a critical inhibitory role during T cell activation, by inactivating membrane-associated Src kinases. However, this model has not been validated by genetic evidence. Here, we demonstrate that PAG-deficient mice display enhanced T cell activation responses in effector, but not in naive, T cells. PAG-deficient mice also have augmented T cell-dependent autoimmu ...[more]