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Fingerprinting antibiotics with PAE-based fluorescent sensor arrays.


ABSTRACT: We outline an evolution process for tongue elements composed of poly(p-aryleneethynylene)s (PAE) and detergents, resulting in a chemical tongue (24 elements) that discerns antibiotics. Cross-breeding of this new tongue with tongue elements that consist of simple poly(p-phenyleneethynylene)s (PPE) at different pH-values leads to an enlarged sensor array, composed of 30 elements. This tongue was pruned, employing principal component analysis. We find that a filial tongue featuring three elements from each original array (i.e. a six element tongue) is superior to either of the prior tongues and the composite tongue in the discrimination of structurally different antibiotics. Such a selection process should be general and give an idea how to successfully generate powerful low-selectivity sensor elements and configure them into discriminative chemical tongues.

SUBMITTER: Han J 

PROVIDER: S-EPMC5656244 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Fingerprinting antibiotics with PAE-based fluorescent sensor arrays.

Han Jinsong J   Wang Benhua B   Bender Markus M   Pfisterer Jessica J   Huang Wei W   Seehafer Kai K   Yazdani Mahdieh M   Rotello Vincent M VM   Rotello Caren M CM   Bunz Uwe H F UHF  

Polymer chemistry 20170331 17


We outline an evolution process for tongue elements composed of poly(<i>p</i>-aryleneethynylene)s (PAE) and detergents, resulting in a chemical tongue (24 elements) that discerns antibiotics. Cross-breeding of this new tongue with tongue elements that consist of simple poly(<i>p</i>-phenyleneethynylene)s (PPE) at different pH-values leads to an enlarged sensor array, composed of 30 elements. This tongue was pruned, employing principal component analysis. We find that a filial tongue featuring th  ...[more]

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