Ontology highlight
ABSTRACT:
SUBMITTER: Ng CL
PROVIDER: S-EPMC5656264 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Ng Caroline L CL Fidock David A DA Bogyo Matthew M
Trends in parasitology 20170705 9
Artemisinin (ART)-based combination therapies are the most efficacious treatment of uncomplicated Plasmodium falciparum malaria. Alarmingly, P. falciparum strains have acquired resistance to ART across much of Southeast Asia. ART creates widespread protein and lipid damage inside intraerythrocytic parasites, necessitating macromolecule degradation. The proteasome is the main engine of Plasmodium protein degradation. Indeed, proteasome inhibition and ART have shown synergy in ART-resistant parasi ...[more]