Ontology highlight
ABSTRACT:
SUBMITTER: Husain M
PROVIDER: S-EPMC5656342 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Husain Marium M Hartman Amber D AD Desai Payal P
Pharmacogenomics and personalized medicine 20171019
Sickle cell disease (SCD) is a monogenetic disease but has a wide range of phenotypic expressions. Some of these differences in phenotype can be explained by genetic polymorphisms in the human globin gene. These polymorphisms can result in different responses to typical treatment, sometimes leading to inadequate therapeutics. Research is revealing more polymorphisms, and therefore, new targets for intervention to improve outcomes in SCD. This area of pharmacogenomics is continuing to develop. We ...[more]