Predictors of anxiety in early-stage Parkinson's disease - Results from the first two years of a prospective cohort study.

ABSTRACT:

Aim

Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD.

Methods

The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline. The primary outcome measure was anxiety, as measured with the State-Trait Anxiety Inventory (STAI). Covariates were age, gender, family history, striatal dopamine transporter binding ratios, and severity of motor and non-motor features of PD at baseline. Data were analyzed using a mixed model analysis.

SUBMITTER: Rutten S 

PROVIDER: S-EPMC5656500 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature