Ontology highlight
ABSTRACT:
SUBMITTER: Nieves-Cintron M
PROVIDER: S-EPMC5656614 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nieves-Cintrón Madeline M Syed Arsalan U AU Buonarati Olivia R OR Rigor Robert R RR Nystoriak Matthew A MA Ghosh Debapriya D Sasse Kent C KC Ward Sean M SM Santana Luis F LF Hell Johannes W JW Navedo Manuel F MF
Scientific reports 20171025 1
Large-conductance Ca<sup>2+</sup>-activated potassium (BK<sub>Ca</sub>) channels are key determinants of vascular smooth muscle excitability. Impaired BK<sub>Ca</sub> channel function through remodeling of BK<sub>Ca</sub> β1 expression and function contributes to vascular complications in animal models of diabetes. Yet, whether similar alterations occur in native vascular smooth muscle from humans with type 2 diabetes is unclear. In this study, we evaluated BK<sub>Ca</sub> function in vascular s ...[more]