Ontology highlight
ABSTRACT:
SUBMITTER: Desgeorges MM
PROVIDER: S-EPMC5656661 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Desgeorges Marine Maud MM Devillard Xavier X Toutain Jérome J Castells Josiane J Divoux Didier D Arnould David Frédéric DF Haqq Christopher C Bernaudin Myriam M Durieux Anne-Cécile AC Touzani Omar O Freyssenet Damien Gilles DG
Scientific reports 20171025 1
In stroke patients, loss of skeletal muscle mass leads to prolonged weakness and less efficient rehabilitation. We previously showed that expression of myostatin, a master negative regulator of skeletal muscle mass, was strongly increased in skeletal muscle in a mouse model of stroke. We therefore tested the hypothesis that myostatin inhibition would improve recovery of skeletal muscle mass and function after cerebral ischemia. Cerebral ischemia (45 minutes) was induced by intraluminal right mid ...[more]