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Synthesis and preliminary assessment of the anticancer and Wnt/?-catenin inhibitory activity of small amide libraries of fenamates and profens.

ABSTRACT: As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/?-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/?-catenin signaling.

SUBMITTER: Mathew B

PROVIDER: S-EPMC5656725 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens.

Mathew Bini B Hobrath Judith V JV Lu Wenyan W Li Yonghe Y Reynolds Robert C RC

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 20170805 11

As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition ...[more]

PMID: 29104411

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