Ontology highlight
ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC5656981 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Tang Junnan J Cui Xiaolin X Caranasos Thomas G TG Hensley M Taylor MT Vandergriff Adam C AC Hartanto Yusak Y Shen Deliang D Zhang Hu H Zhang Jinying J Cheng Ke K
ACS nano 20170920 10
Stem cell transplantation is currently implemented clinically but is limited by low retention and engraftment of transplanted cells and the adverse effects of inflammation and immunoreaction when allogeneic or xenogeneic cells are used. Here, we demonstrate the safety and efficacy of encapsulating human cardiac stem cells (hCSCs) in thermosensitive poly(N-isopropylacrylamine-co-acrylic acid) or P(NIPAM-AA) nanogel in mouse and pig models of myocardial infarction (MI). Unlike xenogeneic hCSCs inj ...[more]