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RNAi targeting Caenorhabditis elegans ?-arrestins has little effect on lifespan.

ABSTRACT: Background: ?-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of ?-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that feeding worms with bacteria expressing double-stranded RNA against each of 24 out of total 29 C. elegans ?-arrestins had little effect on lifespan. Thus, individual C. elegans ?-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of ?-arrestins in aging and longevity.

SUBMITTER: Park S

PROVIDER: S-EPMC5657022 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan.

Park Sangsoon S Jung Yoonji Y An Seon Woo A SWA Son Heehwa G HG Hwang Wooseon W Lee Dongyeop D Artan Murat M Park Hae-Eun H HH Jeong Dae-Eun DE Lee Yujin Y Lee Seung-Jae V SV

F1000Research 20170818

Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that feeding worms with bacteria expressing double-stranded RNA against each of 24 out of total 29 C. elegans α-arrestins had little effect on lifespan. ...[more]

PMID: 29123644

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