Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC5657413 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Chemical science 20150311 5
<i>N</i><sup>6</sup>-Methyladenosine (m<sup>6</sup>A) represents a relatively abundant modification in eukaryotic RNA. Because m<sup>6</sup>A has similar properties to adenosine and a low reactivity, limited research has been focused on this nucleoside. In this study, we revealed an important intermediate in the oxidation of m<sup>6</sup>A through the bicarbonate-activated peroxide system. Over the course of oxidation, we found a new mechanism in which <i>N</i><sup>6</sup>-hydroxymethyladenosine ...[more]