Ontology highlight
ABSTRACT:
SUBMITTER: Henriksson E
PROVIDER: S-EPMC5657447 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Henriksson Emma E Huber Anne-Laure AL Soto Erin K EK Kriebs Anna A Vaughan Megan E ME Duglan Drew D Chan Alanna B AB Papp Stephanie J SJ Nguyen Madelena M Afetian Megan E ME Lamia Katja A KA
Journal of biological rhythms 20170615 4
Metformin is widely used in the treatment of type 2 diabetes to lower blood glucose. Although metformin is a relatively safe and effective drug, its clinical efficacy is variable and under certain circumstances it may contribute to life-threatening lactic acidosis. Thus, additional understanding of metformin pharmacokinetics and pharmacodynamics could provide important information regarding therapeutic use of this widely prescribed drug. Here we report a significant effect of time of day on acut ...[more]