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The relationship between duration of psoriasis, vascular inflammation, and cardiovascular events.

ABSTRACT: BACKGROUND:Psoriasis is associated with risk of cardiovascular (CV) disease (CVD) and a major adverse CV event (MACE). Whether psoriasis duration affects risk of vascular inflammation and MACEs has not been well characterized. OBJECTIVES:We utilized two resources to understand the effect of psoriasis duration on vascular disease and CV events: (1) a human imaging study and (2) a population-based study of CVD events. METHODS:First, patients with psoriasis (N = 190) underwent fludeoxyglucose F 18 positron emission tomography/computed tomography (duration effect reported as a ?-coefficient). Second, MACE risk was examined by using nationwide registries (adjusted hazard ratios in patients with psoriasis (n = 87,161) versus the general population (n = 4,234,793). RESULTS:In the human imaging study, patients were young, of low CV risk by traditional risk scores, and had a high prevalence of cardiometabolic diseases. Vascular inflammation by fludeoxyglucose F 18 positron emission tomography/computed tomography was significantly associated with disease duration (? = 0.171, P = .002). In the population-based study, psoriasis duration had strong relationship with MACE risk (1.0% per additional year of psoriasis duration [hazard ratio, 1.010; 95% confidence interval, 1.007-1.013]). LIMITATIONS:These studies utilized observational data. CONCLUSION:We found detrimental effects of psoriasis duration on vascular inflammation and MACE, suggesting that cumulative duration of exposure to low-grade chronic inflammation may accelerate vascular disease development and MACEs. Providers should consider inquiring about duration of disease to counsel for heightened CVD risk in psoriasis.

SUBMITTER: Egeberg A

PROVIDER: S-EPMC5657544 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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The relationship between duration of psoriasis, vascular inflammation, and cardiovascular events.

Egeberg Alexander A Skov Lone L Joshi Aditya A AA Mallbris Lotus L Gislason Gunnar H GH Wu Jashin J JJ Rodante Justin J Lerman Joseph B JB Ahlman Mark A MA Gelfand Joel M JM Mehta Nehal N NN

Journal of the American Academy of Dermatology 20170818 4

<h4>Background</h4>Psoriasis is associated with risk of cardiovascular (CV) disease (CVD) and a major adverse CV event (MACE). Whether psoriasis duration affects risk of vascular inflammation and MACEs has not been well characterized.<h4>Objectives</h4>We utilized two resources to understand the effect of psoriasis duration on vascular disease and CV events: (1) a human imaging study and (2) a population-based study of CVD events.<h4>Methods</h4>First, patients with psoriasis (N = 190) underwent ...[more]

PMID: 28826925

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Dataset Information

The relationship between duration of psoriasis, vascular inflammation, and cardiovascular events.

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The relationship between duration of psoriasis, vascular inflammation, and cardiovascular events.

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