Ontology highlight
ABSTRACT:
SUBMITTER: Adkar SS
PROVIDER: S-EPMC5657581 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Adkar Shaunak S SS Brunger Jonathan M JM Willard Vincent P VP Wu Chia-Lung CL Gersbach Charles A CA Guilak Farshid F
Trends in molecular medicine 20170905 10
Arthritis represents a family of complex joint pathologies responsible for the majority of musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, are chronic conditions with few or no disease-modifying therapeutics available. Advances in genome engineering technology, most recently with CRISPR-Cas9, have revolutionized our ability to interrogate and validate genetic and epigenetic elements associated ...[more]