Ontology highlight
ABSTRACT:
SUBMITTER: Oetjen LK
PROVIDER: S-EPMC5658016 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cell 20170907 1
Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious environmental stimuli. It is well established that these responses are also associated with chronic inflammatory diseases, including asthma and atopic dermatitis. However, the mechanisms by which inflammatory pathways promote sensations such as itch remain poorly understood. Here, we show that type 2 cytokines directly activate sensory neurons in both mice and humans. Further, ...[more]