Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5658031 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Li Haiou H Lyu Qiang Q Cheng Jianlin J
Journal of proteomics & bioinformatics 20161212 12
Protein structure prediction is an important problem in computational biology, and is widely applied to various biomedical problems such as protein function study, protein design, and drug design. In this work, we developed a novel deep learning approach based on a deeply stacked denoising autoencoder for protein structure reconstruction. We applied our approach to a template-based protein structure prediction using only the 3D structural coordinates of homologous template proteins as input. The ...[more]