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Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.

ABSTRACT: Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABAB-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability-an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.

SUBMITTER: Tchenio A

PROVIDER: S-EPMC5658350 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.

Tchenio Anna A Lecca Salvatore S Valentinova Kristina K Mameli Manuel M

Nature communications 20171026 1

Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABA<sub>B</sub>-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability-an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using ...[more]

PMID: 29074844

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