Ontology highlight
ABSTRACT:
SUBMITTER: Wei Z
PROVIDER: S-EPMC5658400 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wei Zhiyun Z Batagov Arsen O AO Schinelli Sergio S Wang Jintu J Wang Yang Y El Fatimy Rachid R Rabinovsky Rosalia R Balaj Leonora L Chen Clark C CC Hochberg Fred F Carter Bob B Breakefield Xandra O XO Krichevsky Anna M AM
Nature communications 20171026 1
Tumor-released RNA may mediate intercellular communication and serve as biomarkers. Here we develop a protocol enabling quantitative, minimally biased analysis of extracellular RNAs (exRNAs) associated with microvesicles, exosomes (collectively called EVs), and ribonucleoproteins (RNPs). The exRNA complexes isolated from patient-derived glioma stem-like cultures exhibit distinct compositions, with microvesicles most closely reflecting cellular transcriptome. exRNA is enriched in small ncRNAs, su ...[more]