Dataset Information

Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients.

ABSTRACT:

Purpose

Neuropathic cancer pain (NCP) is a common and potentially debilitating symptom in cancer patients. We investigated the prevalence of NCP, as well as its management and association with QOL.

Methods

Cancer patients with pain ?1 on the visual analogue scale (VAS) were surveyed with the Douleur Neuropathique (DN4) questionnaire, the Brief Pain Inventory-Short Form (BPI-SF), and the EuroQOL five dimensions (EQ-5D) questionnaire. The associations between NCP and pain severity or NCP and QOL, while controlling for variables relevant to QOL, were then analyzed.

Results

A total of 2003 patients were enrolled in this survey; the prevalence of NCP was 36.0% (n = 722, 95% CI, 32.5-39.5). We found that NCP in cancer patients was closely correlated to a higher pain severity (BPI-SF; 4.96 ± 1.94 versus 4.24 ± 2.02, p < 0.001), and in patients with NCP, pain more severely interfered with daily living, as compared to those without NCP (BPI-SF; 4.86 ± 2.71 versus 4.41 ± 2.87, p < 0.001). Patients with NCP also had worse QOL than those without NCP, as measured by EQ-5D index score (0.47 ± 0.30 vs. 0.51 ± 0.30, p = 0.005), and this was confirmed using multivariate analysis (p < 0.001), even after controlling for other variables such as age, sex, disease stage, cancer duration, radiotherapy, chemotherapy, and comorbidities. Importantly, adjuvant analgesics were used in less than half of patients with NCP (n = 358, 46.4%).

Conclusions

We found that NCP in cancer patients was significantly associated with a worsened QOL, and current management is inadequate. Therefore, future research aimed at developing improved strategies for management of NCP is required.

SUBMITTER: Oh SY

PROVIDER: S-EPMC5658461 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Publications

Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients.

Oh So Yeon SY Shin Sang Won SW Koh Su-Jin SJ Bae Sang Byung SB Chang Hyun H Kim Jung Han JH Kim Hyo Jung HJ Hong Young Seon YS Park Keon Uk KU Park Jeanno J Lee Kyung Hee KH Lee Na Ri NR Lee Jung Lim JL Jang Joung Soon JS Hong Dae Sik DS Lee Seung-Sei SS Baek Sun Kyung SK Choi Dae Ro DR Chung Jooseop J Oh Sang Cheul SC Han Hye Sook HS Yun Hwan Jung HJ Sym Sun Jin SJ Yoon So Young SY Choi In Sil IS Shim Byoung Yong BY Kang Seok Yun SY Kim Sung Rok SR Kim Hyun Joo HJ

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20170708 12

<h4>Purpose</h4>Neuropathic cancer pain (NCP) is a common and potentially debilitating symptom in cancer patients. We investigated the prevalence of NCP, as well as its management and association with QOL.<h4>Methods</h4>Cancer patients with pain ≥1 on the visual analogue scale (VAS) were surveyed with the Douleur Neuropathique (DN4) questionnaire, the Brief Pain Inventory-Short Form (BPI-SF), and the EuroQOL five dimensions (EQ-5D) questionnaire. The associations between NCP and pain severity o ...[more]

PMID: 28689250

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Project description:BACKGROUND:Both diabetes and hemodialysis can seriously impair patients' health related quality of life (HRQOL). This study seeks to obtain data which will help to address the factors associated with impaired HRQOL in hemodialysis patients with diabetes in Palestine. METHODS:A cross-sectional study was performed in multiple centers in the period from November 2016 to June 2017. We utilized the Arabic version of EuroQoL 5 Dimensions 5 Levels (EQ-5D-5L) scale and EuroQol-visual analogue scale (EQ-VAS) to measure patients' HRQOL. The study was conducted in six dialysis centers in the North of West Bank, Palestine. Descriptive and comparative statistics were used to describe clinical and socio-demographic features of patients. Multiple linear regression analysis was used to determine the association between clinical and socio-demographic factors and HRQOL score. RESULTS:One hundred and forty one diabetic patients undergoing hemodialysis were enrolled in our study. Overall, 52.5% of them (74 patients) were males; the patients had a mean age of 60.32 with 52.5% of them aged below 60. The mean ± standard deviation of EQ-5D-5L index and EQ-VAS score was 0.314 ± 0.4 and 50.85±22.43, respectively. The findings of this study suggest that female patients, uneducated patients, unemployed patients, unmarried patients, and patients with more chronic diseases and comorbidities had a significant poor HRQOL scores (p values <0.05). Variables such as marital status and occupational status were significantly (p < 0.05) associated with the QOL score. More specifically, married status and employed patients positively associated with QOL score (β = 0.22; p = 0.016 and β = 0.27; p = 0.013, respectively). CONCLUSIONS:Among diabetic patients undergoing hemodialysis, married status and being employed were associated with modestly higher scores of QOL. We recommend that healthcare providers give more attention to diabetic dialysis patients who are unemployed and unmarried, as they are at a higher risk of having impaired HRQOL.

Dataset Information

Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients.

Purpose

Methods

Results

Conclusions

Publications

Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients.

Similar Datasets

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