Controlling the activity of quorum sensing autoinducers with light.
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ABSTRACT:
SUBMITTER: Van der Berg JP
PROVIDER: S-EPMC5659144 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Controlling the activity of quorum sensing autoinducers with light.
Van der Berg J P JP Velema W A WA Szymanski W W Driessen A J M AJM Feringa B L BL
Chemical science 20150427 6
Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an <i>Escherichia coli</i> reporter strain, and the expression of target QS genes and pyocyanin produc ...[more]
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