Ontology highlight
ABSTRACT:
SUBMITTER: Rebourcet D
PROVIDER: S-EPMC5659676 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rebourcet Diane D Darbey Annalucia A Monteiro Ana A Soffientini Ugo U Tsai Yi Ting YT Handel Ian I Pitetti Jean-Luc JL Nef Serge S Smith Lee B LB O'Shaughnessy Peter J PJ
Endocrinology 20170901 9
Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results show that the size of the Sertoli cell population that forms during development determines the number of germ cells and Leydig cells that will be present in the adult testis. Simil ...[more]