Ontology highlight
ABSTRACT:
SUBMITTER: Deryugina EI
PROVIDER: S-EPMC5659755 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Deryugina Elena I EI Kiosses William B WB
Cell reports 20170401 3
Intravasation, active entry of cancer cells into the circulation, is often considered to be a relatively late event in tumor development occurring after stromal invasion. Here, we provide evidence that intravasation can be initiated early during tumor development and proceed in parallel to or independent of tumor invasion into surrounding stroma. By applying direct and unbiased intravasation-scoring methods to two histologically distinct human cancer types in live-animal models, we demonstrate t ...[more]