Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network.
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ABSTRACT:
SUBMITTER: Slavin T
PROVIDER: S-EPMC5659836 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network.
Slavin Thomas T Neuhausen Susan L SL Rybak Christina C Solomon Ilana I Nehoray Bita B Blazer Kathleen K Niell-Swiller Mariana M Adamson Aaron W AW Yuan Yate-Ching YC Yang Kai K Sand Sharon S Castillo Danielle D Herzog Josef J Wu Xiwei X Tao Shu S Chavez Tanya T Woo Yanghee Y Chao Joseph J Mora Pamela P Horcasitas Darling D Weitzel Jeffrey J
Cancer genetics 20170817
Few susceptibility genes for gastric cancer have been identified. We sought to identify germline susceptibility genes from participants with gastric cancer from an international hereditary cancer research network. Adults with gastric cancer of any histology, and with a germline DNA sample (n = 51), were retrospectively selected. For those without previously identified germline mutations (n = 43), sequencing was performed for 706 candidate genes. Twenty pathogenic or likely pathogenic variants we ...[more]
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