Ontology highlight
ABSTRACT:
SUBMITTER: Kadam RU
PROVIDER: S-EPMC5659926 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Kadam Rameshwar U RU Juraszek Jarek J Brandenburg Boerries B Buyck Christophe C Schepens Wim B G WBG Kesteleyn Bart B Stoops Bart B Vreeken Rob J RJ Vermond Jan J Goutier Wouter W Tang Chan C Vogels Ronald R Friesen Robert H E RHE Goudsmit Jaap J van Dongen Maria J P MJP Wilson Ian A IA
Science (New York, N.Y.) 20170928 6362
Influenza therapeutics with new targets and mechanisms of action are urgently needed to combat potential pandemics, emerging viruses, and constantly mutating strains in circulation. We report here on the design and structural characterization of potent peptidic inhibitors of influenza hemagglutinin. The peptide design was based on complementarity-determining region loops of human broadly neutralizing antibodies against the hemagglutinin (FI6v3 and CR9114). The optimized peptides exhibit nanomola ...[more]