Ontology highlight
ABSTRACT:
SUBMITTER: Turner CJ
PROVIDER: S-EPMC5660148 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Turner Christopher J CJ Badu-Nkansah Kwabena K Hynes Richard O RO
Angiogenesis 20170630 4
Fibronectin containing alternatively spliced EIIIA and EIIIB domains is largely absent from mature quiescent vessels in adults, but is highly expressed around blood vessels during developmental and pathological angiogenesis. The precise functions of fibronectin and its splice variants during developmental angiogenesis however remain unclear due to the presence of cardiac, somitic, mesodermal and neural defects in existing global fibronectin KO mouse models. Using a rare family of surviving EIIIA ...[more]