Ontology highlight
ABSTRACT:
SUBMITTER: Duyen HTL
PROVIDER: S-EPMC5660158 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20171027 1
The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular organ and also an important site of immune reactions with a high density of dendritic cells (DCs), macrophages and T cells. We obtained skin biopsies and contemporaneous blood samples from patients wi ...[more]